Publications:

Cell-free DNA fragmentation patterns and personalized sequencing reveal circulating tumor DNA in urine and plasma of glioma patients.                                                                       

Mouliere F, Smith CG, Heider K, Su J, Thompson M, Morris J, Wan J, Chandrananda D, Hadfield J, Grzelak M, Hudecova I, Cooper W, Gale D, Eldridge M, Watts C, Brindle K, Rosenfeld N, Mair R.                                   EMBO Mol Med. 2021 13(8):e12881

 

Cell-free DNA technologies for the analysis of brain cancer.

Mair R, Mouliere F.

Br J Cancer. 2022 Feb;126(3):371-378.

 

Measurements of plasma cell-free mitochondrial tumor DNA improves detection of glioblastoma in patient-derived orthotopic xenograft models.                                              

Mair R, Mouliere F, Chandrananda D, Smith C, Gale D, Massie C, Wright A, Brindle K, Rosenfeld N.                 Cancer Res. 2019;79(1):220-230 

 

Non-invasive detection of genomic copy number alterations in primary glioma using short fragments of cell-free DNA in cerebrospinal fluid.                                                               

Mouliere F, Mair R (joint first author), Chandrananda D, Smith C, Gale D, Massie C, Wright A, Brindle K, Rosenfeld N.                                                                                                                              

EMBO Mol Med. 2018 10(12):e9323

 

Metabolic imaging with hyperpolarized [1-13C]pyruvate detects low levels of glycolytic activity that vary with the levels of c-Myc expression in patient-derived xenograft models of glioblastoma.                               Mair R, Wright A, Ros S, Hu DE, Booth TC, Kreis F, Rao J, Watts C, Brindle KM.

Cancer Res. 2018;78(18):5408-5418.

 

[18F]-fluoroethyltyrosine-induced Cerenkov luminescence improves image-guided surgical resection of glioma.

Lewis D, Mair R (joint first author), Wright A, Allinson K, Lyons S, Booth T, Bielik R, Price S, Soloviev D, Brindle K.

Theranostics. 2018;8(14):3991-4002.

 

ctDNA monitoring using patient-specific sequencing and integration of variant reads.

Wan JCM, Heider K, Gale D, Murphy S, Fisher E, Mouliere F, Ruiz-Valdepenas A, Santonja A, Morris J, Chandrananda D, Marshall A, Gill AB, Chan PY, Barker E, Young G, Cooper WN, Hudecova I, Marass F, Mair R, Brindle KM, Stewart GD, Abraham JE, Caldas C, Rassl DM, Rintoul RC, Alifrangis C, Middleton MR, Gallagher FA, Parkinson C, Durrani A, McDermott U, Smith CG, Massie C, Corrie PG, Rosenfeld N.

Sci Transl Med. 2020;12(548)

 

Selecting Short DNA Fragments In Plasma Improves Detection of Circulaing Tumour DNA

Mouliere F, Piskorz A, Chandrananda D, Moore E, Morris J, Smith C, Goranova T, Heider K, Mair R, Supernat A, Gounaris I, Ros S, Wan J, Jiminez-Linan M, Gale D, Brindle K, Massie C, Parkinson C, Brenton, Rosenfeld N.

Sci Transl Med. 2018;10(466).

 

Evolutionary dynamics of residual disease in human glioblastoma.

Spiteri I, Caravagna G, Cresswell GD, Vatsiou A, Nichol D, Acar A, Ermini L, Chkhaidze K, Werner B, Mair R, Brognaro E, Verhaak RGW, Sanguinetti G, Piccirillo SGM, Watts C, Sottoriva A.

Ann Oncol. 2019;30(3):456-463

 

MRI measurements of reporter-mediated increases in transmembrane water exchange enable detection of a gene reporter.

Schilling F, Ros S, Hu DE, D'Santos P, McGuire S, Mair R, Wright AJ, Mannion E, Franklin RJ, Neves AA, Brindle K.

Nat Biotechnol. 2017 Jan;35(1):75-80

 

Brain Tumor Imaging.

Brindle KM, Izquierdo-García JL, Lewis DY, Mair RJ, Wright AJ.                                               

J Clin Oncol. 2017 Jul 20;35(21):2432-2438

 

The value of cell-free DNA for molecular pathology

Stewart CM, Kothari PD, Mouliere F, Mair R, Somnay S, Benayed R, Zehir A, Weigelt B, Dawson SJ, Arcila ME, Berger MF, Tsui DW.

J Pathol. 2018 Apr;244(5):616-627